![]() Dangerous heart rhythm disturbances could result. Such a combination could be life threatening. We worry even more about the combination of amiodarone or dronedarone with grapefruit. In the case of statins, that could mean muscle pains and weakness. That means grapefruit may also increase the risk of adverse reactions. Grapefruit juice can raise blood levels and magnify the effects of such medicines. Heart rhythm medicines amiodarone ( Cordarone, Pacerone), dronedarone ( Multaq) and blood pressure pills felodipine ( Plendil) and nifedipine ( Adalat CC) are also affected by grapefruit. They include some cholesterol-lowering drugs: atorvastatin ( Lipitor), lovastatin ( Mevascor) and simvastatin ( Zocor). Let’s tackle the second issue first: Grapefruit and Drug Interactions:ĭozens of medications are affected by grapefruit. The other has to do with the potential for grapefruit to interact with blood pressure medicine. One has to do with the direct grapefruit effect on blood pressure. The answer to this question is complicated because there are two issues to deal with. When I ran out of grapefruit, I was shocked to see the readings climb again. I continued my medication and ate a grapefruit every day. My medicine bottle says, “avoid grapefruit,” but the past few weeks I gave in to temptation and bought several. My BP was in the 150/90 range, still on the high side. When I went back to my doctor, she dropped the lisinopril and increased the dose of nifedipine. That brought the blood pressure down, but it made me cough. Lately the medicine wasn’t controlling my blood pressure, so my doctor added lisinopril. I take nifedipine for high blood pressure. For this discussion, though, we will try to answer an intriguing question from a reader: “Will grapefruit lower blood pressure?” Grapefruit and Blood Pressure: Other research suggests that red grapefruit helps lower triglycerides and cholesterol ( Journal of Agricultural and Food Chemistry, March 8, 2006). Whether grapefruit would be helpful for overweight humans is less obvious ( Metabolism, July, 2010). Grapefruit also seemed to reduce insulin resistance and inflammation. One study reported that a grapefruit extract reduced weight gain in obese rats ( Journal of Medicinal Food, Aug. It has been promoted for its ability to help people lose weight. Seville oranges (used in orange marmalade), pomelos and tangelos (a cross between tangerines and grapefruits) may also have similar effects, so it is best to avoid these fruits when taking Amlodipine.Grapefruit has a reputation for having lots of health benefits. ![]() Grapefruits are the primary fruit to avoid when taking Amlodipine, including red, pink, white and or Blanco varieties. ![]() ![]() Severe cases of dizziness, headaches, vomiting, joint pain, tiredness are possible, as well as liver and muscle damage leading to kidney failure in severe cases.Ĭan I eat citrus fruit while taking Amlodipine? What happens if I eat grapefruit while taking Amlodipine?Įating grapefruit while on Amlodipine can cause the same side effects as if you were taking a much higher dose of the drug. These higher levels of Amlodipine mean more potent effects of the drug and more substantial side effects. Blocking these enzymes causes the drug to stay around for longer, allowing too much Amlodipine to enter your bloodstream. Eating grapefruit can block the action of these essential enzymes. People have varying levels of these enzymes in their body, so eating grapefruit can affect people differently, even when they both take Amlodipine. Amlodipine is broken down by enzymes (CYP3A4) in the lower intestine. Grapefruit and grapefruit juice can interact with Amlodipine.
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